Why the study?
Acute kidney injury and renal dysfunction are common complications after heart transplantation, and whether perioperative atrial natriuretic peptide could prevent early postoperative decreases in renal function was untested.
Does atrial natriuretic peptide prevent a postoperative decrease in renal function early after heart transplantation?
Does atrial natriuretic peptide prevent a postoperative decrease in renal function early after heart transplantation?
Prophylactic infusion of atrial natriuretic peptide does not significantly reduce the incidence of acute kidney injury or the need for dialysis early after heart transplantation.
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ANP failed to prevent post-transplant renal decline; leaves open whether alternative dosing or timing merits further study.
Tholén et al. (2023) studied this question.
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