Why the study?
Does subcutaneous infusion of buffered furosemide provide equivalent bioavailability and diuresis compared to intravenous administration?
Does subcutaneous infusion of buffered furosemide provide equivalent bioavailability and diuresis compared to intravenous administration?
Subcutaneous buffered furosemide offers complete bioavailability and equivalent diuresis to intravenous administration, potentially enabling outpatient or home decongestion in heart failure.
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Supports feasibility of subcutaneous furosemide for outpatient HF decongestion; hypothesis-generating pending randomized outcome trials.
Sica et al. (2018) studied this question.
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