Cellular calcium waves in cardiomyocytes are driven by ryanodine receptor sensitization mediated by SR overloading via SERCA, rather than predominantly by calcium-induced calcium release, offering new insights into arrhythmia mechanisms.
No takes yet. Share an insight, caveat, or question.
Challenges CICR-dominant Ca wave model; hypothesis-generating for arrhythmia mechanisms, needs intact-heart validation.
KELLER et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: