Population
Isolated rat ventricular myocytes
Comparison
Focal caffeine stimulation, thapsigargin… vs Control conditions (normal Ca2+ loads)
Design
Preclinical
Authors
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Should not alter arrhythmia management; leaves open whether luminal Ca2+ sensitization drives waves in human myocytes.
This preclinical study demonstrates that luminal Ca2+ sensitizes sarcoplasmic reticulum Ca2+ release channels to cytosolic Ca2+, playing a crucial role in the generation of Ca2+ waves in ventricular myocytes.
Lukyanenko et al. (1999) studied this question.
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