Why the study?
Does pretreatment with alpha-adrenergic antagonists prevent myocardial necrosis following microsphere embolization in dogs?
Population
Dogs subjected to systemic embolization with 25 or 50 micrometer microspheres from the left ventricular…
Comparison
Pretreatment with various drugs 10 minutes… vs Embolization without effective drug pretreatment…
Design
Preclinical
Follow-up
24 hours
Authors
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Identifies alpha-1 signaling requirement for microembolic necrosis in dogs; extends mechanistic insight but remains preclinical.
Does pretreatment with alpha-adrenergic antagonists prevent myocardial necrosis following microsphere embolization in dogs?
Mechanical interruption of the coronary microcirculation with 25-micrometer microspheres requires an alpha 1-adrenergic mechanism to produce cardiac necrosis.
Eng et al. (1984) studied this question.
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