Why the study?
Does low-dose aspirin increase the risk of fatal gastrointestinal bleeding in subjects taking it for prevention?
Does low-dose aspirin increase the risk of fatal gastrointestinal bleeding in subjects taking it for prevention?
While low-dose aspirin increases the incidence of major gastrointestinal bleeding, it does not significantly increase the risk of fatal gastrointestinal bleeding, suggesting the primary severe risk of prophylactic aspirin is cerebral hemorrhage.
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Prioritizes fatal over incident GI bleeding for aspirin risk-benefit; extends meta-analyses by challenging incidence-based adoption barriers.
Elwood et al. (2016) studied this question.
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