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August 1, 1967CirculationOpen Access

A Comparative Study of Nitroglycerin and Propranolol

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Why the study?

How do sublingual nitroglycerin and intravenous propranolol affect right ventricular fiber shortening and hemodynamics in patients with and without coronary artery disease?

Population

Patients with and without coronary artery disease (normal and arteriosclerotic subjects)

Design

Other

Authors

ERErwin RobinNorthShore University HealthSystemCCCharles CowanEdith Cowan UniversityPPPritpal S. PuriThe University of Queensland

Discussion

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Implication

May guide acute therapy selection in CAD; leaves open validation of metabolic effects in prospective studies.

Structured PICO

How do sublingual nitroglycerin and intravenous propranolol affect right ventricular fiber shortening and hemodynamics in patients with and without coronary artery disease?

P
Population
Patients with and without coronary artery disease (normal and arteriosclerotic subjects)
I
Intervention
Sublingual nitroglycerin (0.6 mg) and intravenous propranolol (0.1 mg/kg)
O
Outcome
Shortening of right ventricular fibers, hemodynamic parameters, and changes in the oxidation-reduction potential of heart musclesurrogate

Nitroglycerin and propranolol have distinct and sometimes opposing acute hemodynamic and metabolic effects on the myocardium in patients with and without coronary artery disease.

Cite This Study

Robin et al. (1967) studied this question.

synapsesocial.com/papers/6a71586135aa2c282ce2a673https://doi.org/10.1161/01.cir.36.2.175
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on Cardiac Dimensions in Intact Unanesthetized Man1965 · 168 citations
  2. 2THE EFFECTS OF SYMPATHECTOMY ON THE ELECTROCARDIOGRAM AND EFFORT TOLERANCE IN ANGINA PECTORIS1964 · 74 citations