Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing
Why the study?
Does obesity cause endothelial dysfunction in pre-pubertal non-hypertensive children without obstructive sleep apnea syndrome?
Population
105 pre-pubertal non-hypertensive children without obstructive sleep apnea syndrome confirmed by…
Comparison
Obesity (obese children) vs Non-obese children
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May indicate early endothelial dysfunction in obese children; hypothesis-generating and requires prospective validation before clinical implications.
Structured PICO
Does obesity cause endothelial dysfunction in pre-pubertal non-hypertensive children without obstructive sleep apnea syndrome?
P
Population
105 pre-pubertal non-hypertensive children without obstructive sleep apnea syndrome (OSAS) confirmed by polysomnography
I
Intervention
Obesity (obese children)
C
Comparator
Non-obese children
O
Outcome
Endothelial function assessed by time to peak capillary reperfusion after occlusion releasesurrogate
Endothelial dysfunction occurs early in life in obese children independent of sleep-disordered breathing.
Cite This Study
Bhattacharjee et al. (2010) studied this question.