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February 14, 2016Physiological ResearchOpen Access

High-fat feeding for 6 months during aging abolished the infarct size-reduction in WT mice without affecting KO animals, though the extent of injury remained larger in KO mice.

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Why the study?

Does AMPK alpha2-subunit deletion and high-fat diet affect heart function and ischemic tolerance in aged female mice?

Population

Female AMPK alpha2(-/-) (KO) and wild type (WT) mice at 6 and 18 months of age

Comparison

AMPK alpha2-subunit deletion and high-fat… vs Wild type mice and standard diet

Design

Preclinical

Follow-up

6 months

Authors

KSKristýna SlámováFPF PapoušekPJPetra Janovská

Discussion

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Overview

AMPKα2 deletion effects on mouse cardiac function remain preliminary; leaves open translational relevance to human ischemic tolerance.

Structured PICO

Does AMPK alpha2-subunit deletion and high-fat diet affect heart function and ischemic tolerance in aged female mice?

P
Population
Female AMPK alpha2(-/-) (KO) and wild type (WT) mice at 6 and 18 months of age
I
Intervention
AMPK alpha2-subunit deletion and high-fat feeding for 6 months
C
Comparator
Wild type mice and standard diet
O
Outcome
Left ventricular fractional shortening and infarct size induced by global ischemia/reperfusion of isolated heartssurrogate

The adverse effects of AMPK alpha2-subunit deletion and high-fat feeding on heart function and myocardial ischemic tolerance in aged female mice are not additive.

Cite This Study

Slámová et al. (2016) studied this question.

synapsesocial.com/papers/6a7160dcf44fa9f079df2c05https://doi.org/10.33549/physiolres.932979
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Also Consider

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