Adiponectin and Lipoprotein Particle Size

We read with great interest the recently published study by Weiss et al. (1) on adiponectin and lipoprotein particle size. They indicate that adiponectin is favorably associated with the lipoprotein particle size and subclass distribution independent of adiposity and insulin sensitivity in young adults (1). However, they did not check lifestyle-related factors, such as smoking status, which affect the lipoprotein particle size. Although adiponectin levels are not independently associated with stroke or brain infarction (2), adiponectin levels are associated with an increased risk of initial-onset coronary heart disease in older people (3). Moreover, adiponectin gene single nucleotide …