Key result
Low adiponectin levels (lowest vs highest quartile) were associated with higher age- and sex-adjusted odds of ischemic stroke (OR 2.04; 95% CI 1.09-3.80), but not after full risk factor adjustment.
Why the study?
Are lower plasma adiponectin levels independently associated with an increased risk of cerebrovascular disease?
Population
809 subjects drawn from the Jichi Medical School Cohort Study
Comparison
Lowest quartile of plasma adiponectin levels vs Highest quartile of plasma adiponectin levels
Design
Case-control
Follow-up
average of 9.7 years
Authors
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Adiponectin not independently tied to ischemic stroke after full adjustment; leaves open its biomarker value beyond traditional risks.
Case-Control (n=809)
Are lower plasma adiponectin levels independently associated with an increased risk of cerebrovascular disease?
Odds Ratio: 2.04 (95% CI 1.09–3.8)
Plasma adiponectin levels are not independently associated with stroke or brain infarction after adjusting for traditional cardiovascular risk factors, suggesting its use as a predictor is premature.
Matsumoto et al. (2007) conducted a case-control in Cerebrovascular disease (n=809). Low adiponectin levels (lowest quartile) vs. Highest quartile of adiponectin level was evaluated on Ischemic stroke (age- and sex-adjusted) (OR 2.04, 95% CI 1.09 to 3.80). Low adiponectin levels (lowest vs highest quartile) were associated with higher age- and sex-adjusted odds of ischemic stroke (OR 2.04; 95% CI 1.09-3.80), but not after full risk factor adjustment.
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