Why the study?
Understanding the complex interaction networks coordinated by ncRNAs may provide a theoretical basis for developing therapeutics targeting their regulatory effects in thrombopoiesis and primary immune thrombocytopenia.
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Design
Review
ncRNA roles in thrombopoiesis may guide future platelet therapies; leaves open clinical translation.
Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot encode proteins, and a better understanding of the complex interaction networks coordinated by ncRNAs will provide a theoretical basis for the development of therapeutics targeting the regulatory effects of ncRNAs. Platelets are produced upon the differentiation of hematopoietic stem cells into megakaryocytes, 1011 per day, and are renewed every 8–9 days. The process of thrombopoiesis is affected by multiple factors, in which ncRNAs also exert a significant regulatory role. This article reviewed the regulatory roles of ncRNAs, mainly microRNAs (miRNAs), circRNAs (circular RNAs), and long non-coding RNAs (lncRNAs), in thrombopoiesis in recent years as well as their roles in primary immune thrombocytopenia (ITP).
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Li et al. (2022) studied this question.
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