November 1, 1985Biochemistry
An actin-depolymerizing protein (destrin) from porcine kidney. Its action on F-actin containing or lacking tropomyosin
Population
Porcine kidney-derived destrin and F-actin (with or without muscle tropomyosin)
Comparison
Destrin (Mr 19 000 protein) vs Spontaneous depolymerization or F-actin without…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Tropomyosin may protect sarcomeric actin from depolymerization; leaves open destrin's role in cardiac cytoskeletal disease models.
Structured PICO
P
Population
Porcine kidney-derived destrin and F-actin (with or without muscle tropomyosin)
I
Intervention
Destrin (Mr 19 000 protein)
C
Comparator
Spontaneous depolymerization (dilution) or F-actin without tropomyosin
O
Outcome
Rate and mechanism of F-actin depolymerizationsurrogate
Destrin depolymerizes F-actin directly, a process significantly slowed by the presence of tropomyosin, suggesting different mechanisms of depolymerization depending on tropomyosin binding.
Cite This Study
Nishida et al. (1985) studied this question.