January 22, 2010Journal of the American Society of NephrologyOpen Access

Atrap Deficiency Increases Arterial Blood Pressure and Plasma Volume

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Why the study?

Does Atrap deficiency increase arterial blood pressure and plasma volume in mice?

Population

Atrap-deficient (Atrap-/-) mice and wild-type mice

Comparison

Atrap deficiency (genetic knockout) vs Wild-type mice

Design

Preclinical

Authors

MOMona OppermannUniversity Hospital Regensburg BGBernhard GessUniversity of Regensburg FSFrank SchwedaCzech Academy of Sciences, Institute of Physiology

Discussion

Member takes

Implication

Atrap deficiency raises BP and volume in mice; hypothesis-generating for AT1 regulation in human hypertension.

Structured PICO

Does Atrap deficiency increase arterial blood pressure and plasma volume in mice?

Population

Atrap-deficient (Atrap-/-) mice and wild-type mice

Intervention

Atrap deficiency (genetic knockout)

Comparator

Wild-type mice

Outcome

Arterial blood pressure and plasma volumesurrogate

Atrap deficiency in mice leads to increased arterial blood pressure and plasma volume, suggesting Atrap acts as a negative regulator of AT1 receptors in renal tubules.

Cite This Study

Oppermann et al. (2010) studied this question.

synapsesocial.com/papers/6a7162e8ac440176ef2a105b https://doi.org/10.1681/asn.2009060658

View Full Paper

Ask AI

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Atrap Deficiency Increases Arterial Blood Pressure and Plasma Volume

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atrap Deficiency Increases Arterial Blood Pressure and Plasma Volume

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider