Why the study?
Does distal tubule-dominant enhancement of ATRAP inhibit salt-sensitive blood pressure elevation and promote natriuresis in mice?
Does distal tubule-dominant enhancement of ATRAP inhibit salt-sensitive blood pressure elevation and promote natriuresis in mice?
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading in mice.
Distal tubule ATRAP enhancement may blunt salt-sensitive hypertension in mice; leaves open translation to human salt-sensitive BP or therapeutic targets.
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Wakui et al. (2015) studied this question.
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