Fixed combination of amlodipine and lisinopril effectiveness in hypertensive smokers

60 untreated middle-aged patients (45-65 years, mean age 53.6, 31 men) with stage 1-2 hypertension not associated with comorbid cardiovascular disease. A subgroup of 30 patients (mean age 52.7, 40% smokers) received treatment.

Fixed combination of amlodipine and lisinopril (starting dose 5 mg/10 mg, titrated every 14 days until target BP <140/90 mm Hg) for 12 weeks

Blood pressure levels (office BP and ambulatory blood pressure monitoring) at 12 weekssurrogate