What does this research mean for the field?

A once-daily combination of the long-acting calcium channel blocker amlodipine and the ACE inhibitor lisinopril provides significantly greater blood pressure reduction in patients with essential hypertension compared to either drug as monotherapy, even at lower doses. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 2000Postgraduate Medical JournalOpen Access

Evaluation of amlodipine, lisinopril, and a combination in the treatment of essential hypertension

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Why the study?

Does the combination of amlodipine and lisinopril improve blood pressure lowering compared to monotherapy in patients with essential hypertension?

Population

n=24 patients with essential hypertension and baseline diastolic blood pressure between 95 and 104 mm Hg.

Comparison

Combination of amlodipine and lisinopril once… vs Amlodipine monotherapy or lisinopril monotherapy…

Design

RCT, Randomised crossover study as per a prior randomisation schedule, Double…

Authors

MNM.U.R. NaiduNizam's Institute of Medical Sciences PUP.R. UshaDr. Hari Singh Gour University TRT. Ramesh Kumar RaoNizam's Institute of Medical Sciences

Discussion

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Implication

Supports low-dose combination over monotherapy for hypertension control; extends ACEI-CCB data to once-daily regimens.

Structured PICO

Does the combination of amlodipine and lisinopril improve blood pressure lowering compared to monotherapy in patients with essential hypertension?

Population

n=24 patients with essential hypertension and baseline diastolic blood pressure (DBP) between 95 and 104 mm Hg.

Intervention

Combination of amlodipine (2.5 mg or 5 mg) and lisinopril (5 mg or 10 mg) once daily.

Comparator

Amlodipine monotherapy (2.5 mg or 5 mg) or lisinopril monotherapy (5 mg or 10 mg) in a crossover design.

Outcome

Supine and standing blood pressure, specifically achievement of target supine DBP below 90 mm Hg.surrogate

The combination of low-dose amlodipine and lisinopril provides superior blood pressure lowering compared to monotherapy in patients with essential hypertension.

Cite This Study

Naidu et al. (2000) studied this question.

synapsesocial.com/papers/6a19b09b3f3ec013f0deed69 https://doi.org/10.1136/pmj.76.896.350

Topics

Hypertension management

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Evaluation of amlodipine, lisinopril, and a combination in the treatment of essential hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Evaluation of amlodipine, lisinopril, and a combination in the treatment of essential hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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