Why the study?
Does the monocyte to high-density lipoprotein cholesterol ratio (MHR) correlate with carotid artery intima-media thickness and plaque in patients with systemic lupus erythematosus?
Does the monocyte to high-density lipoprotein cholesterol ratio (MHR) correlate with carotid artery intima-media thickness and plaque in patients with systemic lupus erythematosus?
The monocyte to high-density lipoprotein cholesterol ratio (MHR) may serve as a useful non-invasive biomarker for assessing carotid atherosclerosis burden in patients with systemic lupus erythematosus.
MHR was associated with carotid plaque in SLE; hypothesis-generating and requires prospective validation before clinical use.
AIM: The purpose of this study was to evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and carotid atherosclerostic plaque in patients with systemic lupus erythematosus (SLE). METHODS: A total of 214 SLE patients were divided into two groups according to the results of ultrasonic examination: carotid arterial atherosclerotic plaque groups and noncarotid arterial atherosclerosis groups. RESULTS: The values of monocyte to high-density lipoprotein-cholesterol ratio (MHR) increase in carotid arterial atherosclerotic plaque groups compared with noncarotid arterial atherosclerosis groups (0.32 ± 0.18 vs 0.26 ± 0.15; p = 0.015). There was a significant correlation between MHR and carotid artery intima-media thickness (r = 0.228; p = 0.001) in patients with SLE. CONCLUSION: Our study suggests that the values of MHR could be a marker to assess carotid artery intima-media thickness in patients with SLE.
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Wang et al. (2018) studied this question.
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