Key result
Systemic lupus erythematosus was not associated with a significantly higher rate of atherosclerosis compared to matched healthy controls (10% vs 5%, P=0.298).
Why the study?
Is there a relationship between carotid intima-media thickness and serum C-reactive protein levels in patients with systemic lupus erythematosus compared to healthy controls?
Case-Control (n=120)
Is there a relationship between carotid intima-media thickness and serum C-reactive protein levels in patients with systemic lupus erythematosus compared to healthy controls?
Absolute Event Rate: 10% vs 5%
p-value: p=0.298
In patients with systemic lupus erythematosus, there appears to be no significant relationship between serum CRP levels and the progression of atherosclerosis as measured by carotid intima-media thickness.
No increased atherosclerosis in SLE versus controls; leaves open CRP-intima-media thickness link pending prospective studies.
: Background: Patients with systemic lupus erythematous (SLE) are more prone to atherosclerosis and cardiovascular diseases due to atherosclerosis and consequently death. Objectives: The aim of this study was to explore a possible relationship between the intima media thickness (IMT) of carotid arteries and the levels of C-reactive protein (CRP) in SLE patients. Patients and Methods:: Sixty SLE patients and 60 healthy persons, being matched in age, ethnicity, gender and body mass index, were recruited for the study. The thickness of intima-media of the carotid arteries and the levels of CRP were measured using color Doppler ultrasonography and highly sensitive CRP measurement methods, respectively then findings were compared between the two groups. Results:: Ultrasonographic evaluation showed atherosclerosis in 6 (10%) and 3 persons (5%) of the patients and control groups, respectively (P = 0. 298). The mean thickness of intima-media was not significantly different between the two groups (P = 0.31).But the mean level of CRP was significantly higher in patients group (P = 0. 005). Conclusions:: We could not find any relationship between the serum CRP level and the risk of atherosclerosis progression in patients with SLE. Perhaps, SLE alone is not an independentrisk factor for atherosclerosis.
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Zakeri et al. (2012) conducted a case-control in Systemic Lupus Erythematosus (n=120). Systemic lupus erythematosus vs. Healthy controls was evaluated on Atherosclerosis on ultrasonographic evaluation (p=0.298). Systemic lupus erythematosus was not associated with a significantly higher rate of atherosclerosis compared to matched healthy controls (10% vs 5%, P=0.298).
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