La3+ stimulated quiescent Swiss 3T3 and 3T6 cells to enter the DNA-synthesizing S phase of the cell cycle. La3+ and insulin interacted synergistically to increase DNA synthesis. A brief exposure of the cells to soluble LaCl3 optimally stimulated entry into S. La3+ was similar to A13+ in its mitogenic properties (J. Cell. Physiol. 118, 298, 1984), but La3+ was 10 times more potent than A13+.
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Smith et al. (1984) studied this question.
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