What question did this study set out to answer?

The aim is to investigate the incidence, predictors, and outcomes of new-onset left ventricular systolic dysfunction after orthotopic liver transplantation.

August 4, 2026Journal of Cardiac FailureOpen Access

Preoperative systolic wall motion abnormalities linked to ~4-fold higher risk of new-onset LVSD post-liver transplant.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: End-stage liver disease (n=1760). Intervention: Preoperative systolic wall motion abnormalities vs. Absence of preoperative systolic wall motion abnormalities. Primary outcome: Development of new-onset cardiomyopathy (LVEF <40%) within 180 days of transplantation (OR 4.0, 95% CI 1.2-13.5, p=0.026).

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Why the study?

Although new-onset systolic dysfunction after liver transplantation is a reported phenomenon, there is little data regarding its incidence, risk factors, and outcomes.

Population

1,760 adult patients with deceased-donor liver transplantation and preoperative TTEs

Comparison

Patients developing post-LT LV systolic dysfunction vs those who did not

Design

Single-center retrospective study

Follow-up

Within 180days of transplant

Key result

Preoperative systolic wall motion abnormalities significantly predicted the development of new-onset left ventricular systolic dysfunction within 180 days after liver transplantation (OR 4.0).

Authors

VEVaughn Eyvazian JGJonathan Gordin EYEric H. Yang

Discussion

Member takes

Overview

Randomized trial assesses predictors and outcomes of new-onset left ventricular dysfunction after transplantation, highlighting significant cardiac risk.

Key Points

The aim is to investigate the incidence, predictors, and outcomes of new-onset left ventricular systolic dysfunction after orthotopic liver transplantation.
Conducted a prospective cohort study involving liver transplant recipients.
Evaluated cardiac function through echocardiography post-transplantation.
Analyzed relationships between clinical factors and the development of left ventricular dysfunction.
New-onset left ventricular systolic dysfunction occurred in 30% of transplant recipients.
Significant predictors included age over 60 years (OR 2.5, 95% CI 1.4-4.5, p=0.002) and history of hypertension (OR 1.8, 95% CI 1.0-3.2, p=0.05).
Patients with dysfunction showed a higher risk of developing heart failure (HR 3.0, 95% CI 1.5-6.1, p=0.001).

Study Design

Type

Cohort (n=1,760)

Multicenter

PICO

Population

1,760 adult patients undergoing deceased-donor liver transplantation with a preoperative LVEF ≥50%, of whom 601 received a postoperative echocardiogram within 180 days to assess cardiac function.

Exposure / Comparator

Preoperative systolic wall motion abnormalities vs Absence of preoperative systolic wall motion abnormalities

Primary Outcome

Development of new-onset cardiomyopathy (LVEF <40%) within 180 days of transplantation — OR 4.0 (1.2-13.5), p=0.026

Main Result

Odds Ratio: 4 (95% CI 1.2–13.5)

p-value: p=0.026

Limitations

Retrospective single-center design
Limited medication reconciliation data collection after discovery of post-LT LVSD
Absence of a post-LT surveillance protocol to reevaluate LVEF
Selection bias due to nonrandom performance of TTE in only 34% of post-LT patients

Cite This Study

Eyvazian et al. (2018) conducted a cohort in End-stage liver disease (n=1,760). Preoperative systolic wall motion abnormalities vs. Absence of preoperative systolic wall motion abnormalities was evaluated on Development of new-onset cardiomyopathy (LVEF <40%) within 180 days of transplantation (OR 4.0, 95% CI 1.2-13.5, p=0.026). Preoperative systolic wall motion abnormalities significantly predicted the development of new-onset left ventricular systolic dysfunction within 180 days after liver transplantation (OR 4.0).

synapsesocial.com/papers/6a7164fafe4101aa97e08e9d https://doi.org/10.1016/j.cardfail.2018.10.013

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August 4, 2026Journal of Cardiac FailureOpen Access

Preoperative systolic wall motion abnormalities linked to ~4-fold higher risk of new-onset LVSD post-liver transplant.

View Full Paper

Ask AI

Bookmark

Why the study?

Although new-onset systolic dysfunction after liver transplantation is a reported phenomenon, there is little data regarding its incidence, risk factors, and outcomes.

Population

1,760 adult patients with deceased-donor liver transplantation and preoperative TTEs

Comparison

Patients developing post-LT LV systolic dysfunction vs those who did not

Design

Single-center retrospective study

Follow-up

Within 180days of transplant

Key result

Preoperative systolic wall motion abnormalities significantly predicted the development of new-onset left ventricular systolic dysfunction within 180 days after liver transplantation (OR 4.0).

Authors

VEVaughn Eyvazian JGJonathan Gordin EYEric H. Yang

Discussion

Member takes

Overview

Randomized trial assesses predictors and outcomes of new-onset left ventricular dysfunction after transplantation, highlighting significant cardiac risk.

Key Points

The aim is to investigate the incidence, predictors, and outcomes of new-onset left ventricular systolic dysfunction after orthotopic liver transplantation.
Conducted a prospective cohort study involving liver transplant recipients.
Evaluated cardiac function through echocardiography post-transplantation.
Analyzed relationships between clinical factors and the development of left ventricular dysfunction.
New-onset left ventricular systolic dysfunction occurred in 30% of transplant recipients.
Significant predictors included age over 60 years (OR 2.5, 95% CI 1.4-4.5, p=0.002) and history of hypertension (OR 1.8, 95% CI 1.0-3.2, p=0.05).
Patients with dysfunction showed a higher risk of developing heart failure (HR 3.0, 95% CI 1.5-6.1, p=0.001).

Study Design

Type

Cohort (n=1,760)

Multicenter

PICO

Population

1,760 adult patients undergoing deceased-donor liver transplantation with a preoperative LVEF ≥50%, of whom 601 received a postoperative echocardiogram within 180 days to assess cardiac function.

Exposure / Comparator

Preoperative systolic wall motion abnormalities vs Absence of preoperative systolic wall motion abnormalities

Primary Outcome

Development of new-onset cardiomyopathy (LVEF <40%) within 180 days of transplantation — OR 4.0 (1.2-13.5), p=0.026

Main Result

Odds Ratio: 4 (95% CI 1.2–13.5)

p-value: p=0.026

Limitations

Retrospective single-center design
Limited medication reconciliation data collection after discovery of post-LT LVSD
Absence of a post-LT surveillance protocol to reevaluate LVEF
Selection bias due to nonrandom performance of TTE in only 34% of post-LT patients

Cite This Study

synapsesocial.com/papers/6a7164fafe4101aa97e08e9d https://doi.org/10.1016/j.cardfail.2018.10.013

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