Why the study?
Does pre-transplant diastolic dysfunction predict the development of systolic heart failure after liver transplantation?
Population
1284 adult patients who underwent liver transplantation, from which 45 cases and 180 controls were identified.
Comparison
Presence of pre-transplant diastolic dysfunction vs Absence of pre-transplant diastolic dysfunction
Design
Case-control
Follow-up
6 months
Key result
Pretransplant diastolic dysfunction was an independent predictor of systolic heart failure within 6 months after liver transplantation (OR 5.26; 95% CI 1.03-28.57; P=0.04).
Authors
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Pretransplant diastolic dysfunction signals higher post-liver transplant systolic HF risk; leaves open whether targeted monitoring or interventions improve recovery.
Case-Control (n=1,284)
No
Does pre-transplant diastolic dysfunction predict the development of systolic heart failure after liver transplantation?
Odds Ratio: 5.26 (95% CI 1.03–28.57)
p-value: p=0.04
Pre-transplant diastolic dysfunction strongly predicts the development of systolic heart failure early after liver transplantation, highlighting the need for close post-transplant monitoring in these patients.
Sonny et al. (2018) conducted a case-control in Systolic heart failure after liver transplantation (n=1,284). Pretransplant diastolic dysfunction vs. No pretransplant diastolic dysfunction was evaluated on Systolic heart failure (decline in ejection fraction to <45% within 6 months after liver transplantation) (OR 5.26, 95% CI 1.03-28.57, p=0.04). Pretransplant diastolic dysfunction was an independent predictor of systolic heart failure within 6 months after liver transplantation (OR 5.26; 95% CI 1.03-28.57; P=0.04).
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