May 24, 2012Liver International

Peri-transplant mortality was independently related to heart failure (OR 15.11, 95% CI 1.76-129.62), and long-term transplant-free mortality was independently related to baseline diastolic dysfunction (HR 4.82, 95% CI 1.78-13.06).

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Why the study?

Does peri-transplant heart failure and left-ventricular diastolic dysfunction predict mortality and morbidity in cirrhotic patients undergoing liver transplantation?

Population

234 consecutive cirrhotic patients undergoing liver transplantation in a single European center from 1999 to…

Design

Cohort

Follow-up

mean 4 years (0.5-9 years)

Authors

AJAxel JosefssonSahlgrenska University Hospital MFMichael FuHeart Failure & Transplant PAPari AllayhariSahlgrenska University Hospital

Discussion

Member takes

Overview

May support pre-transplant cardiac screening in cirrhosis; leaves open whether treating HF or diastolic dysfunction improves survival.

Structured PICO

Does peri-transplant heart failure and left-ventricular diastolic dysfunction predict mortality and morbidity in cirrhotic patients undergoing liver transplantation?

Population

234 consecutive cirrhotic patients undergoing liver transplantation in a single European center from 1999 to 2007 (mean age 52, 30% women, 36% with alcoholic liver disease, 24% with viral hepatitis, 18% cholestatic liver disease).

Outcome

Post-transplant morbidity and mortality (peri-transplant mortality and long-term transplant-free mortality)hard clinical

Peri-transplant heart failure and baseline diastolic dysfunction are independent predictors of mortality and morbidity in cirrhotic patients undergoing liver transplantation.

Cite This Study

Josefsson et al. (2012) studied this question.

synapsesocial.com/papers/6a712b2d2163a0a01bc556a7 https://doi.org/10.1111/j.1478-3231.2012.02818.x

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May 24, 2012Liver International

Peri-transplant mortality was independently related to heart failure (OR 15.11, 95% CI 1.76-129.62), and long-term transplant-free mortality was independently related to baseline diastolic dysfunction (HR 4.82, 95% CI 1.78-13.06).

View Full Paper

Ask AI

Bookmark

Why the study?

Does peri-transplant heart failure and left-ventricular diastolic dysfunction predict mortality and morbidity in cirrhotic patients undergoing liver transplantation?

Population

234 consecutive cirrhotic patients undergoing liver transplantation in a single European center from 1999 to…

Design

Cohort

Follow-up

mean 4 years (0.5-9 years)

Authors

AJAxel JosefssonSahlgrenska University Hospital MFMichael FuHeart Failure & Transplant PAPari AllayhariSahlgrenska University Hospital

Discussion

Member takes

Overview

May support pre-transplant cardiac screening in cirrhosis; leaves open whether treating HF or diastolic dysfunction improves survival.

Structured PICO

Does peri-transplant heart failure and left-ventricular diastolic dysfunction predict mortality and morbidity in cirrhotic patients undergoing liver transplantation?

Population

Outcome

Post-transplant morbidity and mortality (peri-transplant mortality and long-term transplant-free mortality)hard clinical

Peri-transplant heart failure and baseline diastolic dysfunction are independent predictors of mortality and morbidity in cirrhotic patients undergoing liver transplantation.

Cite This Study

Josefsson et al. (2012) studied this question.

synapsesocial.com/papers/6a712b2d2163a0a01bc556a7 https://doi.org/10.1111/j.1478-3231.2012.02818.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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