Why the study?
The impact of left ventricular diastolic dysfunction on survival after liver transplant was not known, especially when defined using current diagnostic criteria.
Does the presence of left ventricular diastolic dysfunction per the 2016 ASE criteria increase all-cause mortality after liver transplant in patients with end-stage liver disease?
Population
Patients with end-stage liver disease undergoing liver transplant
Comparison
Presence vs absence of left ventricular diastolic dysfunction per 2016 ASE criteria
Design
Systematic review and meta-analysis
Key result
Preoperative left ventricular diastolic dysfunction, defined by the 2016 ASE criteria, was not significantly associated with long-term mortality after liver transplant (OR 0.13).
Authors
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LVDD per 2016 ASE criteria shows no post-LT mortality difference; leaves open need for prospective validation of refined diastolic criteria in transplant risk models.
Systematic Review (n=4,793)
Does the presence of left ventricular diastolic dysfunction per the 2016 ASE criteria increase all-cause mortality after liver transplant in patients with end-stage liver disease?
Odds Ratio: 0.13 (95% CI -0.2–0.47)
Preoperative left ventricular diastolic dysfunction defined by the 2016 ASE criteria was not significantly associated with increased long-term mortality after liver transplant, though evidence is limited by high heterogeneity and few studies.
Martínez et al. (2023) conducted a systematic review in End-stage liver disease (ESLD) (n=4,793). Left ventricular diastolic dysfunction (LVDD) per 2016 ASE criteria vs. Without left ventricular diastolic dysfunction was evaluated on All-cause mortality after liver transplant (OR 0.13, 95% CI -0.20-0.47). Preoperative left ventricular diastolic dysfunction, defined by the 2016 ASE criteria, was not significantly associated with long-term mortality after liver transplant (OR 0.13).
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