Key result
Preoperative grade II diastolic dysfunction was significantly associated with the occurrence of early allograft dysfunction after orthotopic liver transplantation (P<0.003).
Why the study?
The association between the grade of diastolic dysfunction and the occurrence of early allograft dysfunction after liver transplantation remained to be investigated under the 2016 ASE/EACVI guidelines.
Does preoperative grade II diastolic dysfunction increase the risk of early allograft dysfunction in patients undergoing orthotopic liver transplantation?
Observational (n=83)
Does preoperative grade II diastolic dysfunction increase the risk of early allograft dysfunction in patients undergoing orthotopic liver transplantation?
Preoperative grade II diastolic dysfunction is significantly associated with the development of early allograft dysfunction after orthotopic liver transplantation.
May inform preoperative risk stratification in liver transplantation; leaves open whether interventions reduce early allograft dysfunction.
OBJECTIVES: To investigate the association between the grade of diastolic dysfunction (DD) and the occurrence of early allograft dysfunction (EAD) in liver transplant patients following the new 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging (ASE/EACVI) guidelines. METHODS: From January 2015 to December 2019, we retrospectively analyzed 83 patients who underwent orthotopic liver transplantation (OLTx) and their susceptibility to develop EAD according to the grade of preoperative DD. EAD was defined according to the criteria proposed by Olfhoff et al.; DD was defined with four parameters: E/A, e/e', Left Atrium volume, and Tricuspid Regurgitation velocity. RESULTS: According to the ASE/EACVI guidelines grade II DD was detected in 20 patients (24.1%) undergoing OLTx. A statistically significant association was found between grade II DD and the occurrence of EAD (p-value < 0.003). The Kaplan-Meier analysis failed to find any significant difference between the survival probability, nevertheless at the end of a 90-day follow-up period, mortality showed a different trend in classes with more severe diastolic dysfunction. CONCLUSION: According to the ASE/EACVI guidelines from 2016, patients with grade II DD seem to have a higher propensity to develop early allograft dysfunction EAD after OLTx. Our study advises a need for an urgent prospective multicenter study to elucidate the long-term outcomes of liver transplants patients with diastolic dysfunction.
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Vetrugno et al. (2022) conducted an observational in Orthotopic liver transplantation (n=83). Preoperative grade II diastolic dysfunction vs. Other grades of diastolic dysfunction was evaluated on Early allograft dysfunction (EAD) (p=< 0.003). Preoperative grade II diastolic dysfunction was significantly associated with the occurrence of early allograft dysfunction after orthotopic liver transplantation (P<0.003).
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