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January 1, 2021Clinical and Experimental HepatologyOpen Access

The presence of LVDD had no impact on 5-year all-cause mortality (log-rank test nonsignificant).

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Why the study?

Cirrhotic cardiomyopathy includes systolic dysfunction, left ventricular diastolic dysfunction (LVDD), and conduction abnormalities, but the impact of LVDD on mortality in liver transplantation patients needed investigation.

Does left ventricular diastolic dysfunction impact 5-year all-cause mortality in patients undergoing liver transplantation?

Population

266 patients undergoing liver transplantation with EF >= 55% and determinate LVDD status

Comparison

Presence vs absence of LVDD

Design

Single-institution retrospective cohort study

Follow-up

5 years

Authors

HMHemnishil K. MarellaNYNeeraja YedlapatiJKJiten P. Kothadia

Discussion

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Member takes

Overview

LVDD should not alter LT risk stratification or candidacy; leaves open need for prospective validation of updated diastolic criteria in ESLD.

Structured PICO

Does left ventricular diastolic dysfunction impact 5-year all-cause mortality in patients undergoing liver transplantation?

P
Population
266 patients who underwent liver transplantation with ejection fraction ≥ 55% and determinate left ventricular diastolic dysfunction (LVDD) status on transthoracic echocardiogram.
I
Intervention
Presence of left ventricular diastolic dysfunction (LVDD)
C
Comparator
Absence of left ventricular diastolic dysfunction (LVDD)
O
Outcome
5-year all-cause mortalityhard clinical

Left ventricular diastolic dysfunction does not significantly affect 5-year all-cause mortality or immediate post-transplant outcomes in patients undergoing liver transplantation.

Cite This Study

Marella et al. (2021) studied this question.

synapsesocial.com/papers/6a8a774b238a34ecf4722c97https://doi.org/10.5114/ceh.2021.111001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Diastolic Dysfunction Defined Using the 2016 ASE Criteria and Mortality after a Liver Transplant in Patients with End-Stage Liver Disease: A Systematic Review2023
  2. 2Left ventricular diastolic dysfunction per the 2016 ASE criteria and mortality after liver transplant in patients with end stage liver disease: a Systematic Review and Metanalysis2023
  3. 3Diastolic dysfunction: Prevalence and outcome in liver transplantation candidates2025 · 4 citations
  4. 4The predictive value of revised diastolic dysfunction in outcomes of liver transplantation: A propensity score matching analysis2023 · 5 citations
  5. 5A case-cohort study of left ventricular diastolic dysfunction in patients with cirrhosis: the liver–heart axis2023 · 4 citations