Key result
Left ventricular diastolic dysfunction defined by 2016 ASE criteria showed no significant difference in mortality after liver transplant in a meta-analysis of two studies.
Why the study?
The impact of left ventricular diastolic dysfunction on survival after liver transplant was not known, especially when defined using current diagnostic criteria.
Does left ventricular diastolic dysfunction (LVDD) per 2016 ASE criteria increase all-cause mortality after a liver transplant in patients with end-stage liver disease?
Systematic Review
Does left ventricular diastolic dysfunction (LVDD) per 2016 ASE criteria increase all-cause mortality after a liver transplant in patients with end-stage liver disease?
Current evidence is insufficient to definitively link LVDD defined by 2016 ASE criteria to increased mortality after liver transplantation, highlighting the need for prospective studies.
Answers are grounded in this paper and cite their sources.
Pretransplant LVDD by 2016 ASE criteria shows no post-LT mortality difference; leaves open whether older criteria or other CCM features predict outcomes.
Left ventricular diastolic dysfunction (LVDD) is a hallmark of cirrhotic cardiomyopathy and has been linked to a poorer quality of life and worse outcomes in patients with end-stage liver disease. Its impact on survival after a liver transplant (LT) is not known, especially when using current diagnostic criteria to define LVDD. We conducted a systematic review and meta-analysis of the current published literature on mortality after a LT in patients with LVDD. We searched for articles in PubMed, Scopus, EMBASE, Web of Science, and the COCHRANE Central database. We included cohort studies that compared post-transplant outcomes between cirrhotic patients with and without LVDD. Our primary outcome of interest was all-cause mortality after a LT in relation to the presence of LVDD per the 2016 American Society of Echocardiography criteria. A total of 1029 articles were screened during the selection process. Two studies included in the meta-analysis showed no significant difference in mortality, but there was high heterogeneity. A narrative review of other studies that classified diastolic function (DD) using different criteria was also performed, revealing an association with worse outcomes in these patients. High-quality prospective studies using current criteria are needed to confirm these findings.
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González-Martínez et al. (2023) conducted a systematic review in End-stage liver disease. Left ventricular diastolic dysfunction (LVDD) vs. Without LVDD was evaluated on All-cause mortality after a liver transplant. Left ventricular diastolic dysfunction defined by 2016 ASE criteria showed no significant difference in mortality after liver transplant in a meta-analysis of two studies.
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