Key result
Diastolic dysfunction, present in 6.4% of liver transplantation candidates according to revised 2019 criteria, did not significantly impact post-transplant survival (91.7% vs 85.6%, p=0.391).
Why the study?
Diagnostic criteria for cirrhotic cardiomyopathy presenting primarily as diastolic dysfunction were updated in 2019, prompting evaluation of the prevalence and clinical impact of diastolic dysfunction in liver transplantation candidates.
Does diastolic dysfunction impact mortality in adult cirrhotic liver transplantation candidates?
Population
233 adult cirrhotic liver transplantation candidates
Comparison
Diastolic dysfunction by original 2005 vs revised 2019 criteria, and presence vs absence of diastolic dysfunction
Design
Retrospective study
Authors
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Revised 2019 criteria identify DD in 6% of LT candidates vs 72% by 2005 without outcome differences; leaves open prospective validation of clinical utility.
Cohort (n=233)
No
Does diastolic dysfunction impact mortality in adult cirrhotic liver transplantation candidates?
Absolute Event Rate: 91.7% vs 85.6%
p-value: p=0.391
Diastolic dysfunction, defined by the revised 2019 criteria, is present in 6.4% of liver transplant candidates and does not significantly impact overall post-transplant mortality, though lower pre-transplant e' lateral velocity is associated with worse outcomes.
Voet et al. (2025) conducted a cohort in Cirrhosis (Liver transplantation candidates) (n=233). Diastolic dysfunction (2019 revised criteria) vs. No diastolic dysfunction was evaluated on Post-transplant survival (p=0.391). Diastolic dysfunction, present in 6.4% of liver transplantation candidates according to revised 2019 criteria, did not significantly impact post-transplant survival (91.7% vs 85.6%, p=0.391).
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