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August 15, 2005Journal of VirologyOpen Access

Dipyridamole Reversibly Inhibits Mengovirus RNA Replication

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Population

HeLa or L cells infected with mengovirus, luciferase-expressing mengovirus replicons, and Krebs-2-derived in…

Design

Preclinical

Authors

CFCori L. Fata-HartleyMichigan UnitedAPAnn C. PalmenbergUniversity of Wisconsin–Madison

Discussion

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Implication

Offers selective experimental tool for cardiovirus replication studies; leaves open therapeutic translation from this animal model.

Structured PICO

P
Population
HeLa or L cells infected with mengovirus, luciferase-expressing mengovirus replicons, and Krebs-2-derived in vitro system
I
Intervention
Dipyridamole (80 muM)
O
Outcome
Mengovirus plaque formation and viral RNA synthesissurrogate

Dipyridamole is a potent experimental tool that selectively inhibits cardiovirus RNA replication without affecting translation.

Cite This Study

Fata-Hartley et al. (2005) studied this question.

synapsesocial.com/papers/6a71666bf44fa9f079df326fhttps://doi.org/10.1128/jvi.79.17.11062-11070.2005
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts1989 · 124 citations
  2. 2Guanidine-resistant poliovirus mutants produce modified 37-kilodalton proteins1984 · 28 citations
  3. 3Phenotypic Characterization of Three Phylogenetically Conserved Stem-Loop Motifs in the Mengovirus 3′ Untranslated Region2001 · 38 citations
  4. 4Cell-Free, De Novo Synthesis of Poliovirus1991 · 375 citations