Key result
Mengovirus RNA transcripts with short poly(C) tracts were infectious to HeLa cells and showed growth characteristics indistinguishable from parental viruses.
Population
HeLa cells in tissue culture
Comparison
Mengovirus RNA transcripts with short 5'… vs Parental viruses with longer poly tracts
Design
Preclinical
Authors
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Short poly(C) tracts enable mengovirus constructs in vitro; extends basic cardiovirus virology but leaves in vivo roles open.
The length of the poly(C) tract does not play a significant restrictive role for cardiovirus infectivity in tissue culture.
Duke et al. (1989) studied Cardiovirus infectivity. Mengovirus RNA transcripts with short poly(C) tracts vs. Parental viruses with longer poly(C) tracts was evaluated on Infectivity and growth characteristics in HeLa cells. Mengovirus RNA transcripts with short poly(C) tracts were infectious to HeLa cells and showed growth characteristics indistinguishable from parental viruses.
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