April 1, 2000Journal of VirologyOpen Access

Mengovirus and Encephalomyocarditis Virus Poly(C) Tract Lengths Can Affect Virus Growth in Murine Cell Culture

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Population

Murine cell populations including four hematopoietically derived cell lines and two murine fibroblast cell…

Comparison

Mengo-type cardioviruses with long poly tracts vs Mengo-type cardioviruses with short poly tracts

Design

Preclinical

Authors

LMLee R. MartinScripps Research Institute ZNZane C. NealUniversity of Wisconsin System MMM S McBrideUniversity of Wisconsin–Madison

Discussion

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Implication

Poly(C) tract length restricts mengovirus replication in murine macrophages; leaves open its contribution to in vivo virulence.

Structured PICO

Population

Murine cell populations including four hematopoietically derived cell lines (CH2B, RAW 264.7, A20.J, and P815) and two murine fibroblast cell lines [L929 and L(Y)]

Intervention

Mengo-type cardioviruses with long poly(C) tracts (vMwt)

Comparator

Mengo-type cardioviruses with short poly(C) tracts (vMC24 and vMC0)

Outcome

Virus replication and cytopathic effectssurrogate

Poly(C) tract length in mengovirus determines viral replication capacity in murine hematopoietic cells, explaining its role in virulence.

Cite This Study

Martin et al. (2000) studied this question.

synapsesocial.com/papers/6a86a2771d4e7816c90cfe96 https://doi.org/10.1128/jvi.74.7.3074-3081.2000

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Mengovirus and Encephalomyocarditis Virus Poly(C) Tract Lengths Can Affect Virus Growth in Murine Cell Culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mengovirus and Encephalomyocarditis Virus Poly(C) Tract Lengths Can Affect Virus Growth in Murine Cell Culture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider