Population
HeLa cells and mice
Comparison
Mengovirus mutants with varying poly tract… vs Wild-type mengovirus
Design
Preclinical
Authors
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Hypothesis-generating for mengovirus attenuation; leaves open relevance to human picornavirus pathogenesis.
The study demonstrates that the mengovirus poly(C) tract length correlates with virulence and plaque size, and identifies the 3' flanking region as critical for viral replication.
Martin et al. (1996) studied this question.
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