April 1, 1995Journal of VirologyOpen Access

Encephalomyocarditis viruses with short poly(C) tracts are more virulent than their mengovirus counterparts

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Population

HeLa cells and mice

Comparison

Encephalomyocarditis virus strain R with short… vs Equivalent mengoviruses with similar short polys…

Design

Preclinical

Authors

Discussion

Short poly(C) tracts yield modest EMCV attenuation dependent on context; leaves open generalization to other picornaviruses.

Population

HeLa cells and mice

Intervention

Encephalomyocarditis virus strain R (EMCV-R) with short poly(C) tracts (C4, C9, C20)

Comparator

Equivalent mengoviruses with similar short poly(C)s and wild-type EMCV-R

Outcome

Virulence/pathogenicity and plaque size

Short-tract poly(C)-mediated attenuation of encephalomyocarditis viruses is highly dependent on viral genomic context.

Hahn et al. (1995) studied this question.

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