Population
C57BL/6 mice (n=25 for one group), pigs, and cynomolgus macaques
Design
Preclinical
Follow-up
Up to 90 days postinfection
Authors
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Short poly(C) EMCV strains cause fatal cardiac failure in pigs; challenges poly(C) length requirements for virulence and leaves open human cardiac relevance.
A naturally occurring EMCV strain with a short poly(C) tract is pathogenic across multiple species, causing fatal cardiac failure in pigs and encephalitis in mice, demonstrating that a long poly(C) tract is not strictly required for virulence.
LaRue et al. (2003) studied this question.
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