December 1, 1999Journal of VirologyOpen Access

Dependence of Echovirus 9 on the Enterovirus RNA Replication Inhibitor 2-(α-Hydroxybenzyl)-Benzimidazole Maps to Nonstructural Protein 2C

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Population

Echovirus 9 model (recombinant viruses)

Design

Preclinical

Authors

Discussion

Highlights minimal genetic determinant of echovirus phenotype in animals; leaves open relevance to human pathogenesis or antivirals.

Population

Echovirus 9 model (recombinant viruses)

Intervention

HBB [2-(alpha-hydroxybenzyl)-benzimidazole] exposure and sequence analysis/mutation

Outcome

HBB dependence phenotypesurrogate

In an echovirus 9 model, HBB dependence maps to the nonstructural protein 2C, specifically requiring a single point mutation at C(4782)U.

Hadaschik et al. (1999) studied this question.

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