Key result
Complete resistance to HBB or guanidine in echovirus-9 is due to single but different point mutations in the non-structural protein 2C, which do not alter NTPase activity.
Population
Echovirus-9 variants and expressed viral protein 2C (wild-type and mutants)
Comparison
HBB [2--benzimidazole] and guanidine vs Wild-type echovirus-9 / absence of inhibitors
Design
Preclinical
Authors
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May inform resistance surveillance for picornavirus antivirals; leaves open clinical translation beyond echovirus-9 models.
Resistance to picornavirus replication inhibitors HBB and guanidine in echovirus-9 is mediated by distinct point mutations in viral protein 2C, without altering NTPase activity.
Klein et al. (2000) studied Echovirus-9 infection (in vitro). HBB and guanidine was evaluated on Viral resistance and NTPase activity. Complete resistance to HBB or guanidine in echovirus-9 is due to single but different point mutations in the non-structural protein 2C, which do not alter NTPase activity.
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