May 15, 2020Open Access

The adverse alterations of HDL in quality promote septic ARDS via exacerbated pulmonary endothelial dysfunction

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Why the study?

The adverse changes in HDL composition and function in septic acute respiratory distress syndrome patients remain largely unknown.

Does HDL from septic ARDS patients aggravate acute lung injury compared to normal HDL?

Population

40 patients with septic ARDS and 40 matched normal controls, plus mouse and cell models

Comparison

A-HDL vs N-HDL

Design

Preclinical translational and laboratory comparative study

Authors

LYLiu YangChinese Academy of Sciences SLSijie LiuCapital Medical University SHSilu HanCapital Medical University

Discussion

Member takes

Implication

HDL dysfunction may worsen septic ALI; leaves open whether restoring HDL composition improves clinical outcomes.

Structured PICO

Does HDL from septic ARDS patients aggravate acute lung injury compared to normal HDL?

Population

40 patients with septic ARDS and 40 matched normal controls; C57BL/6 and apoA-I knock-out (KO) mice after cecal ligation and puncture (CLP); Mouse lung microvascular endothelial cells (MLECs)

Intervention

Administration of HDL from septic ARDS patients (A-HDL)

Comparator

Administration of HDL from normal controls (N-HDL)

Outcome

HDL composition changes and severity of acute lung injurysurrogate

Sepsis induces adverse remodeling of HDL quality, which exacerbates acute lung injury by promoting pulmonary endothelial dysfunction.

Cite This Study

Yang et al. (2020) studied this question.

synapsesocial.com/papers/6a716676febe604dd70a11da https://doi.org/10.21203/rs.3.rs-28564/v1

View Full Paper

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May 15, 2020Open Access

The adverse alterations of HDL in quality promote septic ARDS via exacerbated pulmonary endothelial dysfunction

View Full Paper

Ask AI

Bookmark

Why the study?

The adverse changes in HDL composition and function in septic acute respiratory distress syndrome patients remain largely unknown.

Does HDL from septic ARDS patients aggravate acute lung injury compared to normal HDL?

Population

40 patients with septic ARDS and 40 matched normal controls, plus mouse and cell models

Comparison

A-HDL vs N-HDL

Design

Preclinical translational and laboratory comparative study

Authors

LYLiu YangChinese Academy of Sciences SLSijie LiuCapital Medical University SHSilu HanCapital Medical University

Discussion

Member takes

Implication

HDL dysfunction may worsen septic ALI; leaves open whether restoring HDL composition improves clinical outcomes.

Structured PICO

Does HDL from septic ARDS patients aggravate acute lung injury compared to normal HDL?

Population

40 patients with septic ARDS and 40 matched normal controls; C57BL/6 and apoA-I knock-out (KO) mice after cecal ligation and puncture (CLP); Mouse lung microvascular endothelial cells (MLECs)

Intervention

Administration of HDL from septic ARDS patients (A-HDL)

Comparator

Administration of HDL from normal controls (N-HDL)

Outcome

HDL composition changes and severity of acute lung injurysurrogate

Sepsis induces adverse remodeling of HDL quality, which exacerbates acute lung injury by promoting pulmonary endothelial dysfunction.

Cite This Study

Yang et al. (2020) studied this question.

synapsesocial.com/papers/6a716676febe604dd70a11da https://doi.org/10.21203/rs.3.rs-28564/v1

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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