Searching for kinesin's mechanical amplifier
Population
Kinesin motor proteins
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not alter clinical management; extends motor protein models with hypothesis-generating relevance to cardiac cellular transport.
Structured PICO
P
Population
Kinesin motor proteins
I
Intervention
Mutagenesis of the neck regions
O
Outcome
Directional motion along the microtubule and coupling of ATP hydrolysis
Identifies the neck region of kinesin as the mechanical amplifier analogous to the lever-arm of myosin.
Cite This Study
Vale et al. (2000) studied this question.