P6383The predictors of the efficacy of pharmacological cardioversion with class III antiarrhythmic drug - nibentan in patients with persistent atrial fibrillation

Introduction: The choice of cardioversion method (electrical or pharmacological) in patients with atrial fibrillation (AF) has not lost relevance yet. In this regards it is of upmost importance to determine in advance which method of sinus rhythm (SR) restoration will be the most effective for each individual patient. Purpose: To evaluate the possible predictors of the efficacy of pharmacological cardioversion with class III antiarrythmic drug nibentan (Nb) for restoration of SR in patients (pts) with persistent AF. Methods: The study included 56 pts (36 male) from 34 to 74 years (average age 54 y) with persistent AF, with duration of AF from 8 days till 36 months (6,7±6,7 months). Nb was administered in a calculated dose 0,125 mg/kg and used in two bolus injections (0,06 mg/kg each bolus), performed at the interval of 15 minutes. The second bolus of Nb was injected if SR was not restored within 15 minutes after first bolus injection (0,06 mg/kg). Cardioversion was considered successful if SR was restored in 12 hours from the initial bolus of Nb (first bolus). The group of pts with success (n=38) and without success (n=18) of cardioversion were comparatively analyzed based on 20 anamnestic, clinical and instrumental signs.