Why the study?
Does rosiglitazone reduce postischemic myocardial apoptosis in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion?
Population
Male New Zealand rabbits fed normal or high cholesterol diets for 8 weeks, subjected to 60 min of coronary…
Comparison
Rosiglitazone administered for 5 weeks vs Vehicle and normal diet rabbits
Design
Preclinical, randomized
Follow-up
8 weeks of diet, followed by 60 min occlusion and 4 h…
Authors
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Rosiglitazone may protect hypercholesterolemic hearts in ischemia-reperfusion models; leaves open translation to human therapy.
Does rosiglitazone reduce postischemic myocardial apoptosis in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion?
In a rabbit model of hypercholesterolemia, rosiglitazone protected the heart from ischemia/reperfusion-induced myocardial apoptosis and improved functional recovery.
Hong Liu (2004) studied this question.
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