Why the study?
Does rosiglitazone attenuate cardiac hypertrophy in diet-induced hypercholesterolemic rats?
Population
Rats fed a cholesterol-rich diet (diet-induced hypercholesterolemic model)
Comparison
Rosiglitazone and irbesartan vs Untreated rats on a cholesterol-rich diet
Design
Preclinical
Follow-up
6 months
Authors
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Hypothesis-generating in hypercholesterolemic rats; leaves open translation to human cardiac hypertrophy therapy.
Does rosiglitazone attenuate cardiac hypertrophy in diet-induced hypercholesterolemic rats?
Rosiglitazone attenuates cardiac hypertrophy in hypercholesterolemic rats by modulating the local renin-angiotensin system and improving lipid profiles.
Ren et al. (2009) studied this question.
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