Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 14, 2009International Journal of Geriatric Psychiatry

Carotid‐ intima media thickness is independently associated with cognitive decline. The INVADE study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is elevated carotid intima-media thickness associated with the development of cognitive impairment in an elderly population?

Population

3,386 subjects from the INVADE project (Ebersberg, Bavaria), mean age 67.7 years, 41% male.

Comparison

Elevated carotid intima-media thickness at… vs Lower carotid intima-media thickness at baseline

Design

Cohort

Follow-up

2 years

Authors

KSKerstin SanderHBHorst BickelHFHans Förstl

Discussion

Loading...

Member takes

Overview

Elevated C-IMT may flag cognitive vulnerability in elderly; extends prior links but leaves causal role and utility open.

Structured PICO

Is elevated carotid intima-media thickness associated with the development of cognitive impairment in an elderly population?

P
Population
3,386 subjects from the INVADE project (Ebersberg, Bavaria), mean age 67.7 years, 41% male.
I
Intervention
Elevated carotid intima-media thickness (C-IMT) at baseline
C
Comparator
Lower carotid intima-media thickness (C-IMT) at baseline
O
Outcome
Development of new cognitive impairment (evaluated by 6 Item Cognitive Impairment Test [6CIT]) after 2 years

Increased carotid intima-media thickness is an independent predictor of cognitive decline in an elderly population without prevalent cognitive impairment.

Cite This Study

Sander et al. (2009) studied this question.

synapsesocial.com/papers/6a716c9dfebe604dd70a181chttps://doi.org/10.1002/gps.2351
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carotid Intima-Media Thickness and Cognitive Function in Elderly Women: A Population-Based Study2007 · 98 citations
  2. 2Carotid Atherosclerosis Is Associated with Brain Atrophy in Japanese Elders2006 · 30 citations
  3. 3Combined Effects of Hemoglobin A <sub>1c</sub> and C-Reactive Protein on the Progression of Subclinical Carotid Atherosclerosis2005 · 95 citations
  4. 4Relationship Between Circadian Blood Pressure Patterns and Progression of Early Carotid Atherosclerosis2000 · 407 citations
  5. 5The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects1968 · 4,141 citations