Key result
Highest carotid IMT quartile linked to ~201% higher likelihood of cognitive impairment versus lowest quartile.
Why the study?
The potential associations between carotid intima-media thickness and cognitive impairment among patients with acute ischemic stroke were not well established.
Is higher carotid intima-media thickness associated with cognitive impairment in patients with acute ischemic stroke?
Cross-Sectional (n=1,826)
Yes
Is higher carotid intima-media thickness associated with cognitive impairment in patients with acute ischemic stroke?
Higher carotid intima-media thickness is significantly associated with an increased likelihood of cognitive impairment in patients with acute ischemic stroke.
Answers are grounded in this paper and cite their sources.
May flag higher cognitive risk in acute stroke via carotid IMT; hypothesis-generating and requires prospective validation before clinical use.
This study aimed to investigate the potential associations between carotid intima-media thickness and cognitive impairment among patients with acute ischemic stroke and to identify the clinical implications. We measured carotid intima-media thickness (IMT) and performed the Mini-Mental State Examination (MMSE) upon the admission of 1,826 acute ischemic stroke patients. The association between IMT and cognitive impairment evaluated by the MMSE was assessed with a multivariate regression analysis. Other clinical variables of interest were also assessed. After adjusting for potential confounders, participants in the highest IMT quartile had a higher likelihood of having cognitive impairments compared with the lowest IMT quartile (odds ratio: 3.01, 95% confidence interval: 2.07-4.37, p < 0.001). Stratified analyses indicated that this positive correlation was similar for the maxIMT and meanIMT of carotid artery measurements. A positive correlation was found between IMT and cognitive impairment in participants with acute ischemic stroke.
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Yue et al. (2016) conducted a cross-sectional in Acute ischemic stroke (n=1,826). Carotid intima-media thickness vs. Lowest IMT quartile was evaluated on Cognitive impairment (MMSE score < 24) (OR 3.01, 95% CI 2.07-4.37, p=<0.001). Participants in the highest quartile of maximum carotid intima-media thickness had a significantly higher likelihood of cognitive impairment compared with the lowest quartile (OR 3.01).
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