Why the study?
Does KLF15 regulate cardiac remodeling and interstitial fibrosis in response to pressure overload?
Population
Rat model of in vivo aortic coarctation followed by pressure unloading, and in vitro cultured cardiac…
Comparison
In vivo: pressure overload and unloading; In… vs Control conditions (implied)
Design
Preclinical
Authors
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Supports KLF15 targeting to reduce fibrosis in animal models; leaves open translation to human pressure-overload disease.
Does KLF15 regulate cardiac remodeling and interstitial fibrosis in response to pressure overload?
KLF15 acts as an essential negative regulatory factor in cardiac remodeling and fibrosis by modulating TGF-β, CTGF, and MRTF-A expression.
Yu et al. (2015) studied this question.
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