The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules corrected
Why the study?
Does the lack of CD4 or CD8 molecules prevent the induction of experimental autoimmune myocarditis in mice?
Population
Mice lacking CD4 or CD8 molecules after gene targeting (CD8-/- and CD4-/- mice)
Comparison
Injection with cardiac myosin to induce… vs CD4+/-CD8+/- control mice
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not yet alter myocarditis management in immunodeficiencies; leaves open T-cell-independent initiation mechanisms for human validation.
Structured PICO
Does the lack of CD4 or CD8 molecules prevent the induction of experimental autoimmune myocarditis in mice?
P
Population
Mice lacking CD4 or CD8 molecules after gene targeting (CD8-/- and CD4-/- mice)
I
Intervention
Injection with cardiac myosin to induce organ-specific autoimmune myocarditis
C
Comparator
CD4+/-CD8+/- control mice
O
Outcome
Development and severity of autoimmune myocarditissurrogate
The lack of CD4+ or CD8+ T cells does not prevent the initiation of autoimmune myocarditis, but these cells regulate disease severity, which may explain autoimmunity in CD4 immunodeficiencies.
Cite This Study
Penninger et al. (1993) studied this question.