Why the study?
Does the rate of symptomatic thromboembolic events differ among patients given intraoperative tranexamic acid when different postoperative prophylactic regimens (aspirin, warfarin, dalteparin) are used after primary THA and TKA?
Population
2046 patients who underwent primary total hip arthroplasty or total knee arthroplasty from 2007 to 2009…
Comparison
Intraoperative tranexamic acid combined with… vs Comparison among the three prophylactic regimens.
Design
Cohort
Authors
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Similar low symptomatic DVT/PE rates across regimens with tranexamic acid; hypothesis-generating, requires randomized confirmation before practice change.
Does the rate of symptomatic thromboembolic events differ among patients given intraoperative tranexamic acid when different postoperative prophylactic regimens (aspirin, warfarin, dalteparin) are used after primary THA and TKA?
Intraoperative tranexamic acid during primary THA and TKA is associated with a low rate of thromboembolic complications even when less aggressive thromboprophylactic regimens like aspirin alone are used.
Gillette et al. (2012) studied this question.
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