Why the study?
Transcatheter closure of inferior sinus venosus defect remains contraindicated, prompting exploration of whether closure with patent ductus arteriosus occluders is feasible.
Does transcatheter closure with a PDA occluder following 3D-printed model simulation improve cardiac dimensions safely in patients with inferior sinus venosus defect?
Does transcatheter closure with a PDA occluder following 3D-printed model simulation improve cardiac dimensions safely in patients with inferior sinus venosus defect?
Transcatheter closure of inferior sinus venosus defects using a PDA occluder guided by 3D-printed models is feasible, safe, and effectively reduces right ventricular dimensions.
May support transcatheter ISVD closure feasibility in select cases; leaves open safety and efficacy in prospective trials.
Background: Transcatheter closure of inferior sinus venosus defect (ISVD) is still contraindication. To explore whether transcatheter closure with patent ductus arteriosus (PDA) occluders is possible for ISVD. Methods: From June 2014 to March 2021, 12 patients were recruited diagnosed as <25 mm ISVD. The three-dimensional printing (3DP) heart model was produced based on multi-slice computed tomography (MSCT) scans. Preoperative closure simulation was planned on the personalized 3D model for each patient. Follow-up including electrocardiography (ECG), transthoracic echocardiography (TTE), and X-ray was traced. Results: 3DP models of 12 patients were successfully printed. Twelve patients had been diagnosed with <25 mm ISVD and 4 of them had another secundum atrial septal defect (ASD). All patients were produced interventional therapy successfully. PDA occluder was implanted to closed ISVD, and ASD was closed using ASD occluder simultaneously. The average diameter of ISVD measured by TTE was (12.67±3.80), and the average diameter of sagittal axes and longitudinal axes measured by the 3D-printed model was (17.08±3.20) and (18.42±4.62) mm, respectively. The average size of PDA (diameter of pulmonary artery side) was (28.17±3.35) mm. Compared with the preoperative, the X-ray cardiothoracic ratio (0.51±0.04 vs. 0.47±0.06, P=0.007) and the right ventricle anterior-posterior diameter (31.17±5.65 vs. 24.58±3.75 mm, P<0.001) of postoperative was significantly decreased. During the average (47.75±27.52) months follow-up, it has achieved satisfying results, and there were no severe adverse events such as device transposition, death, and pericardial tamponade occurred. Conclusions: Assisting by 3D heart model, transcatheter closure of ISVD with PDA occluder had an excellent outcome. This method provides a new considerable treatment strategy for ISVD.
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Zhou et al. (2022) studied this question.
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