Effects of alcohol on systemic and pulmonary hemodynamics in normal humans
Why the study?
Does ethanol ingestion alter systemic and pulmonary hemodynamics in healthy humans?
Population
6 healthy physicians, aged 27-36 years
Comparison
0.5 g/kg of ethanol diluted to 15% in fruit… vs Baseline measurements before ingestion
Design
Cohort
Follow-up
2 hours
Authors
Discussion
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Implication
Low-dose ethanol may acutely raise pulmonary pressures in healthy subjects; leaves open relevance to cardiopulmonary disease.
Structured PICO
Does ethanol ingestion alter systemic and pulmonary hemodynamics in healthy humans?
P
Population
6 healthy physicians, aged 27-36 years
I
Intervention
0.5 g/kg of ethanol diluted to 15% (w/v) in fruit juice ingested within 30 min
C
Comparator
Baseline measurements before ingestion
O
Outcome
Systemic and pulmonary hemodynamics measured via Swan-Ganz thermodilution catheter every half-hour for 2 hourssurrogate
Low-dose alcohol ingestion in healthy individuals transiently increases pulmonary artery pressure and vascular resistance while subsequently decreasing left ventricular preload.
Cite This Study
Koskinen et al. (1986) studied this question.