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February 1, 1989Antimicrobial Agents and ChemotherapyOpen Access

Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells

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Authors

RHR. Anthony Vere HodgeCanon (United Kingdom)RPRobert M. PerkinsYale New Haven Hospital

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Hodge et al. (1989) studied this question.

synapsesocial.com/papers/6a716eeaac440176ef2a2089https://doi.org/10.1128/aac.33.2.223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease1975 · 341 citations
  2. 2Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture1987 · 238 citations
  3. 3Synthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines1987 · 155 citations
  4. 4Influence of acyclovir and bucyclovir on nucleotide pools in cells infected with herpes simplex virus type 11986 · 17 citations
  5. 5Metabolism and mode of action of (R)-9-(3,4-dihydroxybutyl)guanine in herpes simplex virus-infected vero cells.1986 · 39 citations