Key result
Hemorrhagic hypotension markedly increases circulating angiotensin levels, whereas equivalent aortic constriction causes no increase.
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Angiotensin blood levels were measured in anesthetized dogs under different experimental conditions. In hemorrhagic hypotension, a marked and progressive increase in angiotensin blood levels was detected. No increase was found when a similar reduction in renal perfusion pressure was elicited by constriction of the aorta above the renal arteries. A high dose of norepinephrine infused simultaneously with the constriction of the aorta produced a significant increase in angiotensin blood levels which was lower than the one detected after hemorrhage. A potentiation of the effect of dog renin injections on angiotensin blood levels by bleeding was shown. It is concluded that the rise in angiotensin blood levels after hemorrhage is not solely due to a decreased renal perfusion pressure. Other possibilities are discussed.
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Scornik et al. (1964) studied Hemorrhagic hypotension. Hemorrhagic hypotension, suprarenal aortic constriction, norepinephrine infusion, and renin injections vs. Suprarenal aortic constriction alone was evaluated on Angiotensin blood levels. Hemorrhagic hypotension caused a marked progressive increase in dog angiotensin blood levels, whereas similar renal perfusion pressure reduction via aortic constriction caused no increase.
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